Left common trunkus pulmonary veins have genetic background and poor rhythm outcome after atrial fibrillation catheter ablation

Abstract Funding Acknowledgements Type of funding sources: None. Background There is a genetic background in pulmonary vein (PV) development and atrial fibrillation (AF). However, the trait PV variations their rhythm outcome after AF catheter ablation (AFCA) unclear. Objective We explored clinical characteristics long-term outcomes patients with variation or left common trunkus (LCT)-PV. Methods included 2,897 (74.0% male, age 59.0 ± 10.7 years, 66.3% paroxysmal AF) available genome-wide association study results, cardiac computed tomogram data, protocol-based regular follow-up from Yonsei cohort database. defined LCT-PV when upper lower separate at >10 mm distal to antrum margin. both accessory PVs. analyzed polygenic risk score (PRS) 12 AF-associated genes (DSP, GJA1, HCN4, KCNQ1, NPPA, PITX2, RYR2, SCN5a, SHOX2, ATP2A2, TBX3, TBX5) AFCA. Results found 296 (10.2%) 102 (3.5%). PRS 1,227 single nucleotid polymorphisms (SNPs) was significantly higher (p=4.93e-08) (p=1.95e-20). The had CHA2DS2VASc scores (p=0.024) epicardial adipose tissue volume (p=0.034). During 39.7 34.8 months period, recurrence rate than counter part sub-group (Log-rank p=0.036), but not overall variations. highest 10% independently associated AFCA (HR 2.10, 95% CI 1.21-3.63, p=0.008). Conclusions Among who underwent AFCA, variation, including LCT-PV, has significant background. post-AFCA high PRS, especially AF.